Cefoxitin Sodium for Injection

Sterile powder for injection IM/IV

[Indications]

Used for the following infections caused by the bacterial susceptible to cefoxitin:

  • Upper/lower respiratory infection
  • Urinary tract infection, including gonorrhea without complications
  • Peritonitis and other infections in abdominal cavity and pelvic cavity
  • Septicemia (typhoid included)
  • Gynecology infections
  • Bone, joint soft tissue infection
  • Endocarditis

Active to anaerobe and stable to β-lactamase, Cefoxitin is specially used on the infections caused by aerobe and anaerobe, and the infections caused by the bacteria susceptible to cefoxitin and producing β-lactamase.

[Administration and dosage]

Cefoxitin may be administered intramuscularly, intravenously or intravenously guttae. For adults: the recommended dosage is 1～2g per 6-8 hours.

According to sensitivity extents of pathogenic bacteria and patient's conditions, the dosage should be adjusted:

Type of infection

Daily total dosage

Administration

Uncomplicated infections (pneumonia, urinary system infection, skin infection)

3~4g

1g per 6～8 hours, IM or IV gtt.

Medium or severe infections

6~8g

1g per 4 hours, or 2g per 6～8 hours, IV gtt.

Infections needing large doses of antibiotics to cure (e.g., gas gangrene)

12g

2g per 4 hours, or 3g per 6 hours, IV gtt.

For patients with renal insufficiency, dosages should be adjusted accordingly, as per creatinine clearance rate:

Renal function

Creatinine clearance(ml/min)

Dosages

Intervals

Mild damage

50~30

1~2g

Per 8 ~12 hours

Medium damage

29~10

1~2g

Per 12 ~24 hours

Severe damage

9~5

0.5~1.0g

Per 12 ~24 hours

Renal failure

<5

0.5~1.0g

Per 24 ~48 hours

For intramuscular injection: per g of the sterile powder should be reconstituted with 2ml (0.5%) lidocaine; for intravenous injection: per g of the sterile powder should be reconstituted with 10ml sterile water for injection; for intravenously guttae: per 1～2 g of the sterile powder should be reconstituted with 50ml or 100ml NaCl solution, or 5% or 10% glucose solution.